PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma [J]. Baseline PET/CT imaging parameters for prediction of treatment outcome in Hodgkin and diffuse large B cell lymphoma: A systematic review. official website and that any information you provide is encrypted Methods 188, 2029. Features are extracted from a region of interest (ROI) by mathematical-statistical processing, resulting in many quantifiable features to characterize different image properties10. WebNeurolymphomatosis: an uncommon manifestation of lymphoma detection and therapeutic monitoring through 18F-fluorodeoxyglucose positron-emission tomography and computed tomography imaging. Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the first international workshop on interim-PET-scan in lymphoma. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: Fischman, A.J. I am trying like below but nothing happens Prognostic significance of baseline metabolic tumor volume in relapsed and refractory Hodgkin lymphoma. CAS WebA case report of synchronous primary gastric hodgkin lymphoma and lung adenocarcinoma and literature review Jew Win Kuan 1, Noraidah Masir 2 1 Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia 2 Prince Court Medical Centre, Pantai Premier Pathology, Kuala This material may not otherwise be downloaded, copied, printed, stored, transmitted or reproduced in any medium, whether now known or later invented, except as authorized in writing by the AAFP. To achieve reproducible results, we determined the final DS using the qPET approach23. https://doi.org/10.1182/blood-2018-05-852129 (2018). ; Bernardo, M.P. 22, 3539. Please note that many of the page functionalities won't work as expected without javascript enabled. were able to differentiate Glioblastoma from CNS Lymphoma with MR-derived radiomics and predict the survival of lymphoma patients with radiomics from 18F-FDG-PET data12. This site needs JavaScript to work properly. The diagnosis of lymphoma is made using an open lymph node biopsy, based off morphology, immunohistochemistry, and flow cytometry. Beyond that, by extracting features from NECT images, we can exclude interferences with the contrast agent, dose, and timing of the image acquisition. and T.E. Image a shows an example slice of a 3D ROI segmenting a lymphoma manifestation in the upper mediastinum. 2022 Oct;29(10):6254-6264. doi: 10.1245/s10434-022-12191-y. ; Abdelkhalek, E.R. Fedorov, A. N Engl J Med. 48, 471480 (2007). Kwee TC, Kwee RM, Nievelstein RA. Outcome analysis of high-dose chemotherapy and autologous stem cell transplantation in adolescent and young adults with relapsed or refractory Hodgkin lymphoma. Deauville score was developed at Guy's and Saint Thomas Hospital in London after an international meeting at Deauville, France in 2009. R package version 6.093. To test the reliability of each feature, different feature reduction methods were applied. Rinsho Ketsueki. ; methodology, S.N.N., J.M.M.R., I.G.S. The study was conducted in accordance with the Declaration of Helsinki. WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Methods: It is recommended by the National Comprehensive Cancer Network guidelines and Lugano response criteria for the standardized quantification of FDG uptake in lymphoma manifestations6. van Griethuysen, J. J. M. et al. Revelle, W. psych: Procedures for Psychological, Psychometric, and Personality Research. Imaging in staging of malignant lymphoma: A systematic review. The median age of patients at diagnosis of non-Hodgkin lymphoma is 67 years, and the median age at death is 76. The Spearman between Deauville score and SUV max approach was 0.31 (95% CI, 0.230.38). Rep. 6, 23428. https://doi.org/10.1038/srep23428 (2016). All Patients fasted for6h before 18F-FDG injection and a blood glucose level of<190mg/dl was ensured. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. People without Google Scholar. The authors declare no competing interests. Considering the ROC analysis, 32 features from the dataset of scanner A and 19 from the dataset of scanner B showed an AUC of at least 0.7. 10 Results showed superior results for patients who were PET negative. Rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, dermatomyositis, and celiac disease are inflammatory conditions that increase the risk of lymphoma through disease-specific causes and the chronic use of immunosuppressive medications.8, Modifiable risk factors include current or former tobacco use9 and obesity (body mass index of 30 kg per m2 or higher).10 Breast implants and long-term pesticide exposure have also been associated with non-Hodgkin lymphoma.1113, Lymphoma commonly presents as painless adenopathy. 2018 Dec;24(12):2501-2508. doi: 10.1016/j.bbmt.2018.07.025. https://www.mdpi.com/openaccess. Terasawa, T.; Lau, J.; Bardet, S.; Couturier, O.; Hotta, T.; Hutchings, M.; Nihashi, T.; Nagai, H. Fluorine-18-fluorodeoxyglucose positron emission tomography for interim response assessment of advanced-stage Hodgkins lymphoma and diffuse large B-cell lymphoma: A systematic review. ; Hudson, M.M. doi: 10.1002/14651858.CD007941.pub3. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). The relevant cutoff was between DS3 and DS4 and defined by a qPET value of 1.323: lesions equal or above were classified as DS4-positive, lesions below as DS4-negative. "Score 3 should be interpreted according to the clinical context but in many Hodgkin Lymphoma patients indicates a good prognosis with standard treatment." The study was designed to test if the PET-negative rate after two cycles of BV-AVD was superior to 75%. and JavaScript. PET/CT scanning and reconstruction details are summarized in Table 3. Eur. Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial. https://doi.org/10.2967/jnumed.116.179648 (2017). 21 features overlapped. Furth, C.; Steffen, I.G. PET-positive suture granuloma of abdominal wall 56 years post-appendicectomy mimicking recurrence of Table 4 offers a summary. J Nucl Med 2009;50 Suppl 1:21S-30S. Lancet Oncol. Comparison of first-line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma. Younes A, Gopal AK, Smith SE, et al. ; Barrington, S.F. WebInterim PET/CT scan was performed after 23 cycles of therapy, and the response was assessed using the Deauville 5-point scales (5-PS) and a semi-quantitative assessment using the SUVmax reduction rate (SUVmax). WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Haploidentical Transplants with Post-Transplant Cyclophosphamide for Relapsed or Refractory Hodgkin Lymphoma: The Role of Comorbidity Index and Pretransplant Positron Emission Tomography. Feature papers represent the most advanced research with significant potential for high impact in the field. (Deauville score 1 to 2) interim PET/CT negative (Deauville score 3) interim PET/CT Of these, only median remains after applying different feature reduction methods. The https:// ensures that you are connecting to the First-degree relatives of patients with non-Hodgkin lymphoma and Hodgkin lymphoma have a respective 1.7-fold and 3.1-fold increased risk of developing lymphoma. volume12, Articlenumber:20008 (2022) The new staging system incorporates two symptom-based classifications: A (absence of symptoms) and B (presence of fever, weight loss, and night sweats) for Hodgkin lymphoma. The left row shows the AUCs of Scanner A, and the right row the AUCs of Scanner B. We assessed the efficacy and safety of brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (BV-AVD) in previously untreated, early-stage unfavorable Hodgkin lymphoma (ClinicalTrials.gov identifier: NCT02292979). Unable to load your collection due to an error, Unable to load your delegates due to an error. Cheson BD, Fisher RI, Barrington SF, Cavalli F, Schwartz LH, Zucca E. Biggi A, Gallamini A, Chauvie S, Hutchings M, Kostakoglu L, Gregianin M. Haioun C, Itti E, Rahmouni A, Brice P, Rain JD, Belhadj K. Hutchings M, Barrington SF. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Comparison of commonly used SUV metrics for differentiation between paediatric tumours. Ann Hematol. Bhakta, N.; Liu, Q.; Yeo, F.; Baassiri, M.; Ehrhardt, M.J.; Srivastava, D.K. This was a retrospective study involving 52 patients (male:female 26:26, age range 816 years, mean standard deviation 12 2.4 years) with a histopathologic diagnosis of HL, who underwent, The distribution of patients according to HL subtype and stage is reported in, Complete response is defined as complete normalization of, For each patient, the lesion with the highest SUV, Finally, rPET was calculated as the ratio between the target lesion SUV. ; data curation, S.N.N., L.J.J., J.R., I.G.S. and B.H. Raanani P, Shasha Y, Perry C, Metser U, Naparstek E, Apter S. Schaefer NG, Hany TF, Taverna C, Seifert B, Stumpe KD, von Schulthess GK. https://doi.org/10.3390/jpm13030445, Ibrahim, Firuz, Michela Gabelloni, Lorenzo Faggioni, Subramanyam Padma, Arun R. Visakh, Dania Cioni, and Emanuele Neri. They found that CT density correlated with 18F-FDG uptake, 68Ga-DOTATOC uptake, and 68Ga-PSMA uptake and suggested a Hounsfield scale to differentiate benign from malignant lymph nodes. Rogasch, J. M. et al. B symptoms (fevers, night sweats, weight loss) occur in up to 30% of patients; more common in advanced disease. Usually, the target lesion was the one with the visually highest DS. Med. Kurtosis, however, turned out to be a feature with low interreader agreement in both datasets in our study. Google Scholar. Results: For 202 patients treated with chemotherapy with or without radiation therapy, the 5-year FFP was 89% (95% confidence interval 85%-93%). The 2-year progression-free survival (PFS) was 97.3% (95% CI, 91.9 to 99.1) and 92.6% (95% CI, 81.4% to 97.2%) in the BV-AVD and ABVD arms, respectively. Diagn. We included a total of 75 PET/CT datasets acquired in 43 patients. Aleman, B.M.P. WebIn addition, Hodgkin lymphoma study groups of adults use a threshold of erythrocyte sedimentation rate of more than 50 mm in the first hour in patients without B symptoms and an erythrocyte sedimentation rate of more than 30 mm in the first hour in those with B symptoms as a risk factor. Verloh, N.; Einspieler, I.; Utpatel, K.; Menhart, K.; Brunner, S.; Hofheinz, F.; van den Hoff, J.; Wiggermann, P.; Evert, M.; Stroszczynski, C.; et al. Google Scholar. The results of all feature reduction methods are provided in the supplementary Tables S6a (Scanner A) and S6b (Scanner B). See permissionsforcopyrightquestions and/or permission requests. Long-term survival and competing causes of death in patients with early-stage Hodgkins disease treated at age 50 or younger. An official website of the United States government. The Lugano classification system further modified staging by incorporating positron emission tomography/computed tomography (PET-CT) results to determine the staging of the lymphoma(Table 319). We use cookies on our website to ensure you get the best experience. In the meantime, to ensure continued support, we are displaying the site without styles ; visualization, S.N.N., L.J.J. Exp Hematol Oncol. Post-therapy DS showed a sensitivity, specificity, PPV, NPV and accuracy of 66.7%, 97.8%, 95.7%, 80% and 94.2%, repsectively. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Lancet. Ibrahim, F.; Gabelloni, M.; Faggioni, L.; Padma, S.; Visakh, A.R. PET/CT (b,c) show this manifestation to be FDG-positive. suggested a link between the non-contrast-enhanced CT-derived texture parameter kurtosis and shorter progression-free survival of lymphoma patients in an 18F-FDG-PET/CT study, including patients with Hodgkin lymphoma and aggressive Non-Hodgkin lymphoma14. permission provided that the original article is clearly cited. Hodgkin's lymphoma. Radiomics for precision medicine: Current challenges, future prospects, and the proposal of a new framework. High rMTV41% (rMTVhigh , 4.4 cm3 ) predicted significantly poorer EFS in patients with DS 4-5 (HR, 3.70; p = .014). Correlation between SUVmax and CT radiomic analysis using lymph node density in PET/CT-based lymph node staging. Google Scholar. Cancer Res. The feature median from NECT concordantly has a high sensitivity for DS4+ Hodgkin manifestations on two different scanners and thus could provide a surrogate for increased metabolic activity in PET/CT. ; resources, H.A. Published by Wolters Kluwer -. WebTailoring treatment in patients with Hodgkin lymphoma (HL) is paramount to maximize outcomes while avoiding unnecessary toxicity. Barrington, S.F. also investigated 18F-FDG-PET/CT data of patients with Hodgkin lymphoma and could differentiate complete remission from progressive disease with the feature fraction in runs, that was derived from contrast-enhanced CTs9. Scores of 1 and 2 are considered to be negative and 4 and 5 are considered to be positive. Increased x-ray attenuation in malignant vs. benign mediastinal nodes in an orthotopic model of lung cancer. In vivo confirmation of altered hepatic glucose metabolism in patients with liver fibrosis/cirrhosis by. future research directions and describes possible research applications. Four patients were PET positive at the end of ABVD Therefore, interreader agreement was assessed to drop low-reproducible features, and different feature reduction methods were performed to reduce the number of variables. Analysis of MRI and CT-based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models. 2. https://doi.org/10.1016/j.ymeth.2020.06.020 (2021). This feature could be easily applied on NECT images to estimate relevant metabolic activity when a PET scan is unavailable. Open lymph node biopsy should be used to definitively diagnose lymphoma. Please enable it to take advantage of the complete set of features! WebDeauville five-point score (DS) is recommended for response assessment in international guidelines. Patients with a Deauville score of 1 to 2 were considered PET negative and randomized to either 30 Gy IFRT or no further treatment, and patients with a Deauville score of 3 to 5 underwent a fourth cycle of ABVD and IFRT. Subsequent chemotherapy toxicities include neuropathy, cardiotoxicity, and secondary cancers such as lung and breast, and should be considered in the shared decision-making process to select a treatment regimen. and L.J.J.. We applied different methods to reduce the number of features in both datasets separately by dropping features with a correlation of more than 95% using the Hmisc package for R33 (Version 4.7.1), applying the minimum redundancy maximum relevance method from the praznik package for R34 (Version 11.0.0) selecting 20 (mrmr20) and 10 (mrmr10) features and with the recursive feature elimination (rfe) from the caret package for R35 (Version 6.0.93). The current five-year survival rate for non-Hodgkin lymphoma is 72.0%, and for Hodgkin lymphoma it is 86.6%. ; Fisher, R.I.; Barrington, S.F. Concordance was defined as agreement between the DS assigned and the line of treatment. Subjects and Methods: A total of 100 eligible consecutive patients underwent F-18 FDG PET-CT scans between January 2014 and December 2015. Ferrari, C.; Niccoli Asabella, A.; Merenda, N.; Altini, C.; Fanelli, M.; Muggeo, P.; De Leonardis, F.; Perillo, T.; Santoro, N.; Rubini, G. Pediatric Hodgkin lymphoma: Predictive value of interim. Elhamady, H.Y. PET/CT mediastinal and liver FDG uptake: Effects of biological and procedural factors. Breast Implant-Associated Anaplastic Large Cell Lymphoma. PET data were acquired from the skull base to the proximal femora in 3D acquisition mode (acquisition time, 23min per bed position). Ganeshan, B. et al. WebHodgkin Lymphoma and certain types of non-Hodgkin lymphomas. Hodgkin lymphoma is most commonly diagnosed at 20 to 34 years of age; however, the median age at death is 68 because of the higher survival rate among younger patients.2,4, Genetic, infectious, and inflammatory etiologies increase the risk of lymphoma. Reconstructed spatial resolution and contrast recovery with Bayesian penalized likelihood reconstruction (Q.Clear) for FDG-PET compared to time-of-flight (TOF) with point spread function (PSF). However, a clear tendency towards one texture feature or feature class that distinctly correlates with increased FDG uptake has not emerged yet. Connors JM, Jurczak W, Straus DJ, Ansell SM, Kim WS, Gallamini A, Younes A, Alekseev S, Ills , Picardi M, Lech-Maranda E, Oki Y, Feldman T, Smolewski P, Savage KJ, Bartlett NL, Walewski J, Chen R, Ramchandren R, Zinzani PL, Cunningham D, Rosta A, Josephson NC, Song E, Sachs J, Liu R, Jolin HA, Huebner D, Radford J; ECHELON-1 Study Group. sharing sensitive information, make sure youre on a federal 75 PET/CT examinations of 43 patients on two different scanners were included. Ilivitzki, A.; Radan, L.; Ben-Arush, M.; Israel, O.; Ben-Barak, A. Avigdor A, Bulvik S, Levi I, Dann EJ, Shemtov N, Perez-Avraham G. Engert A, Haverkamp H, Kobe C, Markova J, Renner C, Ho A.