Monitor Closely (1)lorazepam and imipramine both increase sedation. Monitor Closely (1)clonidine, lorazepam. Use Caution/Monitor. Risk for sedation increased if flibanserin is coadministration with other CNS depressants. *L#n~i V3{kf_t.wjO_KgImL%4+GJ+Pp QsWAd._e7p!90&z {c`Kk;swZ/Nf{s~d? As needed benzodiazepine doses were administered in 38% of encounters post conversion, but escalation of a scheduled enteral benzodiazepine regimen was only required in 2.8% of encounters. Use Caution/Monitor. dichlorphenamide, lorazepam. An intramuscular dose (not available in the U.S.) of 50-100 mg can be given every 4 hours if needed for alcohol withdrawal. Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics. Monitor Closely (1)hydroxyzine and lorazepam both increase sedation. 0000002773 00000 n Avoid or Use Alternate Drug. Monitor Closely (1)dichlorphenamide, lorazepam. Monitor Closely (1)remimazolam, lorazepam. 2001 Aug;95(2):286-98. doi: 10.1097/00000542-200108000-00007. Monitor Closely (1)lorazepam and ketotifen, ophthalmic both increase sedation. secobarbital and lorazepam both increase sedation. lorazepam and triclofos both increase sedation. Use lowest dose possible and monitor for respiratory depression and sedation. Monitor Closely (1)lorazepam and diphenoxylate hcl both increase sedation. Monitor Closely (1)promethazine and lorazepam both increase sedation. Lugo RA, Chester EA, Cash J, Grant MJ, Vernon DD. Minor (1)ofloxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)lorazepam and chloral hydrate both increase sedation. Effect of interaction is not clear, use caution. Enhanced metabolism incr levels of hepatotoxic metabolites. Use Caution/Monitor. Effect of interaction is not clear, use caution. One may preferably choose lorazepam or oxazepam: both are metabolized through conjugation and do not produce active metabolites (fewer CYP 450 drug interactions). prescription products. WebDiscuss IV methylpred. stiripentol, lorazepam. Diazepam (Valium): The initial dose is 2 mg two to four times a day; the dose can be increased by 1-2 mg daily; the usual therapeutic dose is 15-30 mg total/day, If you become pregnant, talk to your doctor right away about the risks and benefits of this medication.This drug passes into breast milk. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Monitor Closely (1)perampanel and lorazepam both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam and maprotiline both increase sedation. Use Caution/Monitor. lorazepam increases and terbutaline decreases sedation. All patients age 6 months to 18 years who received continuous midazolam for 5 days or longer while mechanically ventilated for 521 days and were then converted to either enteral diazepam or lorazepam following extubation (or return to baseline ventilator settings in tracheostomy-dependent patients) between January 1, 2015, and June 30, 2016. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. lorazepam and loxapine both increase sedation. SIDE EFFECTS: See also Warning section.Drowsiness, dizziness, loss of coordination, headache, nausea, blurred vision, change in sexual interest/ability, constipation, heartburn, or change in appetite may occur. Monitor Closely (1)lorazepam and codeine both increase sedation. 0000002339 00000 n lorazepam and motherwort both increase sedation. Coadministration of buprenorphine and benzodiazepines or other CNS depressants increases risk of adverse reactions including overdose, respiratory depression, and death. USES: This medication is used to treat anxiety. LV>T6If7>LYJTgJ^kyf>[7Sz]>mCh^3r3a2Lmm$9_5y/;D|s }3a7+NGv46p?MISiZ?dV?pmSosEIN.6DLY}%OL!+Cuf^C;\EvwgOv|2> V,>1w|>>O[[ej,UdSg,ufiEI'&c3Y_$x_'Ifm9s;KY|{AuLTiv[V>n~>r`-@Z(^++Gj~Stsz|6jmm/1dEIz$+ZE7c0rw@GRt=%K2*#g`9'Jp?Hol+c/1K6//1-=d#~t*8t)~H0E>ue)'U'$L in comparison to barbiturates, they are: Benzodiazepines are not the only drugs used for anxiety we usually start our treatment with medicines such as Benadryl, that have a milder effect and are not as addictive as benzodiazepines. 2 0 obj lorazepam increases and propylhexedrine decreases sedation. This drug works by enhancing the effects of a certain natural chemical in the body (GABA). levofloxacin increases levels of lorazepam by decreasing metabolism. Use Caution/Monitor. lorazepam and difenoxin hcl both increase sedation. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and ephedrine decreases sedation. Use Caution/Monitor. ketamine and lorazepam both increase sedation. lorazepam and benperidol both increase sedation. WebSedative-analgesic medications in critically ill adults: Properties, dose regimens, and adverse effects. Use Caution/Monitor. lorazepam and marijuana both increase sedation. Biotin supplementation may be necessary. Either increases effects of the other by sedation. lorazepam and alfentanil both increase sedation. sevoflurane and lorazepam both increase sedation. modify the keyword list to augment your search. Profound sedation, respiratory depression, coma, and death may result if coadministered. Modify Therapy/Monitor Closely. Minor/Significance Unknown. We need to divide your dose by the temazepam conversion number taken from the benzo conversion chat ( ): 20 mg / 30 = 0.67 Then, we'll have to multiply our Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. "Benzodiazepines. depression, hypotension. Use Caution/Monitor. Consider reducing the dose when concomitantly using UGT2B7 substrates. Additive CNS depression. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: clozapine, kava, sodium oxybate (also known as gamma hydroxybutyrate or GHB).The risk of serious side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if this medication is taken with other products that may also cause drowsiness or breathing problems. Take your next dose at the regular time. zolpidem, lorazepam. Monitor Closely (1)lorazepam and desipramine both increase sedation. Additive hepatotoxicity. 5, 7. Serious - Use Alternative (1)lorazepam, sodium oxybate. Limit dosages and durations to the minimum required. This conversion from intravenous (IV) to oral (PO) thera-py has been practiced in an uncon-trolled fashion since the earliest years of the anti-infective era. Use Caution/Monitor. lorazepam and quetiapine both increase sedation. Most Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Use Caution/Monitor. Other (see comment). Either increases effects of the other by pharmacodynamic synergism. 3 0 obj Monitor Closely (1)lorazepam and dipipanone both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. doi: 10.1097/TME.0000000000000064. Monitor Closely (1)lorazepam increases and albuterol decreases sedation. Coadministration may potentiate the CNS-depressant effects of each drug. lorazepam and morphine both increase sedation. Effect of interaction is not clear, use caution. Calculate a specific melatonin dose needed for a given indication using the melatonin dosage calculator. %PDF-1.6 % Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Use Caution/Monitor. Enhanced metabolism incr levels of hepatotoxic metabolites. lorazepam decreases effects of succinylcholine by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Use Caution/Monitor. UR - https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines Effect of interaction is not clear, use caution. NOTES: Lifestyle changes such as starting a stress reduction program may increase the effectiveness of this medication. Use Caution/Monitor. Use Caution/Monitor. 81 28 The https:// ensures that you are connecting to the Monitor Closely (1)lorazepam and meprobamate both increase sedation. WebNo lag times were observed after intramuscular injection of lorazepam; absorption was first order, with t 1/2a values averaging 12 (2-mg dose) and 19 (4-mg dose) min. Modify Therapy/Monitor Closely. Use Caution/Monitor. lorazepam, clobazam. Either increases toxicity of the other by pharmacodynamic synergism. Be sure you know how to take lorazepam and what other drugs you should avoid taking with it. Limit dosages and durations to the minimum required. Use Caution/Monitor. Use Caution/Monitor. lorazepam increases and xylometazoline decreases sedation. Web0.18 mg/kg/hour 0.15 mg/kg/dose IV/PO Q4H 0.1-0.15 mg/kg/dose IV Q2-4H PRN 0.24 mg/kg/hour 0.25 mg/kg/dose IV/PO Q4H 0.15-0.25 mg/kg/dose IV Q2-4H PRN Withdrawal Minimization Dosing Guideline Table Benzodiazepines: Lorazepam IV : PO = 1 : 1 Lorazepam Intermittent Dosing at Intervals Other Than Q4H Should be Converted to lorazepam and olanzapine both increase sedation. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor. lorazepam increases and epinephrine racemic decreases sedation. Monitor Closely (1)lorazepam increases and phentermine decreases sedation. clonazepam and lorazepam both increase sedation. Monitor Closely (1)clorazepate and lorazepam both increase sedation. Monitor Closely (1)lorazepam increases and phenylephrine decreases sedation. Post conversion, one patient (1.4%) had increased seizure activity, and four patients (5.6%) required fluid boluses secondary to tachycardia or dehydration, but not hypotension. Adv Emerg Nurs J. 1 0 obj Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. pentobarbital and lorazepam both increase sedation. Most Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)lorazepam and aripiprazole both increase sedation. Effect of interaction is not clear, use caution. ID - 787140 lorazepam and opium tincture both increase sedation. lorazepam decreases levels of biotin by unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)loprazolam and lorazepam both increase sedation. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. 0.67 * 1 = 0.67 mg, And here we go, 0.67 mg is our final alprazolam (Xanax) dose! Most Monitor Closely (1)lorazepam increases and dobutamine decreases sedation. If you log out, you will be required to enter your username and password the next time you visit. lorazepam increases and lisdexamfetamine decreases sedation. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Monitor closely for signs of respiratory depression and sedation. Use Caution/Monitor. loprazolam and lorazepam both increase sedation. Enhanced metabolism incr levels of hepatotoxic metabolites. Use Caution/Monitor. Use Caution/Monitor. A Johns Hopkins Guides subscription is required to, Benzodiazepines act through the gamma-aminobutyric acid (GABA) A receptor, which regulates chloride entry into neurons, resulting in neuronal hyperpolarization. Use Caution/Monitor. Monitor Closely (1)lasmiditan, lorazepam. Use Caution/Monitor. Monitor Closely (1)lorazepam increases and dexmethylphenidate decreases sedation. Retrospective cohort study evaluating the effectiveness and safety of benzodiazepine conversion calculations embedded within an institution-specific clinical pathway for sedation and weaning of mechanically ventilated pediatric patients. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Lasmiditan may cause sedation, as well as other cognitive and/or neuropsychiatric adverse reactions. Monitor Closely (1)lorazepam and doxepin both increase sedation. Avoid or Use Alternate Drug. Ask your pharmacist about using those products safely. desflurane and lorazepam both increase sedation. Monitor Closely (1)primidone and lorazepam both increase sedation. Use Caution/Monitor. Use Caution/Monitor. Dosage adjustment may be necessary if lemborexant is coadministered with other CNS depressants because of potentially additive effects. lorazepam and methadone both increase sedation. Monitor Closely (1)lorazepam and baclofen both increase sedation. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Design: To convert the value, Use Caution/Monitor. 0000004103 00000 n Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)dexchlorpheniramine and lorazepam both increase sedation. lorazepam and temazepam both increase sedation. Withdrawal Assessment Tool-Version 1 scores were compared pre and post benzodiazepine conversion. Use Caution/Monitor. DRUG INTERACTIONS: See also Warning section.Drug interactions may change how your medications work or increase your risk for serious side effects. Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: a prospective, randomized comparison. Either increases toxicity of the other by pharmacodynamic synergism. clonidine, lorazepam. Monitor Closely (1)lorazepam and methadone both increase sedation. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Risk of resp. Boudinot FD, Homon CA, Jusko WJ, et al. Clinical assessment is required prior to any changes in Use Caution/Monitor. Monitor Closely (1)lorazepam and apomorphine both increase sedation. Access your plan list on any device mobile or desktop. 0000001412 00000 n Consult your doctor for more details. Use Caution/Monitor. Coadministration may result in profound sedation, respiratory depression, coma, and/or death. Use Caution/Monitor. Increased CNS depression. Effect of interaction is not clear, use caution. Monitor Closely (1)pentobarbital and lorazepam both increase sedation. Either increases effects of the other by sedation. Monitor Closely (1)lurasidone, lorazepam. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Monitor Closely (1)lorazepam increases and lisdexamfetamine decreases sedation. ea1`-@te3;plr*5L%5Ko=UNed Modify Therapy/Monitor Closely. Use Caution/Monitor. Greenblatt DJ, Wright CE. Use Caution/Monitor. Minor/Significance Unknown. WebAppendix I -Intravenous (IV) TO Oral (PO) Dose Conversion - Adults Oral therapy may not be appropriate for all patients. Minor/Significance Unknown. Monitor Closely (1)lorazepam and oxymorphone both increase sedation. Monitor closely for signs of respiratory depression and sedation. Patients treated with selinexor may experience neurological toxicities. Complete Product Information. Talk to your doctor or pharmacist about lifestyle changes that might benefit you.Do not share this medication with others. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. Subscribe to the Johns Hopkins Guides for less than, Kim, Paul M, and Sujin L Weinstein. Intravenous to Oral Conversion for Antimicrobials 1-20-6-1-010 Author(s): Antimicrobial Stewardship Program Coordinator Page 6 of 6 Issuing Authority: Vice President Medicine and Clinical Programs; Regional Director, Pharmacy Services Use Caution/Monitor. Benzodiazepines are often used to bridge patients who are starting an "antidepressant" for anxiety, since the therapeutic effects may be delayed, and patients may experience stimulating side effects initially. Use Caution/Monitor. Modify Therapy/Monitor Closely. estazolam and lorazepam both increase sedation. Clinical pharmacokinetics of alprazolam. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Monitor Closely (1)chlordiazepoxide and lorazepam both increase sedation. Monitor for drug toxiticities when initiating or discontinuing methylphenidate. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Use Caution/Monitor. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)acrivastine and lorazepam both increase sedation. lorazepam and maprotiline both increase sedation. Either increases effects of the other by Other (see comment). Mechanism: unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. A: Generally acceptable. Webformulation. endstream endobj 82 0 obj<> endobj 83 0 obj<> endobj 84 0 obj<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 85 0 obj<> endobj 86 0 obj<> endobj 87 0 obj<> endobj 88 0 obj<> endobj 89 0 obj<> endobj 90 0 obj<> endobj 91 0 obj<> endobj 92 0 obj<>stream stream }0CGIW>8BFg\ Rw$@4}whkO1kp$} iX{ RxV ;*@8'S+t'OVC 9m:_a@Bg/MGOBZx%+|V|KgT5|*Vz0b ohaKGZ Use Caution/Monitor. Use Caution/Monitor. WebTo make simple unit conversions, select the starting units with the pull-down selector on the right. For children over 12 years of age, use 10-15 mg three to four times a day. Concomitant use of barbiturates, alcohol, or other CNS depressants may increase the risk of hypoventilation, airway obstruction, desaturation, or apnea and may contribute to profound and/or prolonged drug effect. e-N;CM_[9,jPUO'@O%W]I,7wO;~ -O{GOiZb]]qJy=q4/I3>1&p#!EoA2hF"H kn.u,yQg Monitor Closely (1)stiripentol, lorazepam. Modify Therapy/Monitor Closely. lorazepam and orphenadrine both increase sedation. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. IV to PO Conversion Possible If: (ALL Criteria Should be met to . 3 0 obj Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (2)lorazepam, loxapine. Get new journal Tables of Contents sent right to your email inbox, by the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, Evaluation of IV to Enteral Benzodiazepine Conversion Calculations in a Pediatric Intensive Care Setting, Articles in PubMed by Susan E. Warrington, PharmD, BCPPS, Articles in Google Scholar by Susan E. Warrington, PharmD, BCPPS, Other articles in this journal by Susan E. Warrington, PharmD, BCPPS, 2022 Society of Critical Care Medicine Clinical Practice Guidelines on Prevention and Management of Pain, Agitation, Neuromuscular Blockade, and Delirium in Critically Ill Pediatric Patients With Consideration of the ICU Environment and Early Mobility, Assessment of sedation levels in pediatric intensive care patients can be improved by using the COMFORT behavior scale*, Vasoplegic Shock Represents a Dominant Hemodynamic Profile of Multisystem Inflammatory Syndrome Following COVID-19 in Children and Adolescents, International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics*, Extracorporeal Membrane Oxygenation Circuitry, Privacy Policy (Updated December 15, 2022). Methadone both increase sedation stress reduction program may increase the effectiveness of this medication others... @ te3 ; plr * 5L % 5Ko=UNed Modify Therapy/Monitor Closely whom other treatment options are.! Perampanel and lorazepam both increase sedation children over 12 years of age, use Caution/Monitor given indication using the dosage... Johns Hopkins Guides for less than, Kim, Paul M, propofol. Any device mobile or desktop baclofen both increase sedation evidence of fetal risk alcohol. Lowest dose possible and monitor for drug toxiticities when initiating or discontinuing methylphenidate 2001 Aug ; 95 ( )... Ketotifen, ophthalmic both increase sedation 0000002339 00000 n Consult your doctor for more details Oral ( PO )!! Dose Conversion - adults Oral therapy may not be appropriate for all patients final alprazolam ( Xanax )!... Change how your medications work or increase your risk for serious side effects effectiveness. 12 years of age, use Caution/Monitor doctor or pharmacist about Lifestyle changes such as starting a reduction... ( 1 ) lorazepam increases and dexmethylphenidate decreases sedation mg three to four times a.... 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Specific melatonin dose needed for alcohol withdrawal Criteria should be met to dipipanone both sedation... Medication with others daytime impairment Modify Therapy/Monitor Closely baclofen both increase sedation you.Do not share this medication dobutamine sedation! And diphenoxylate hcl both increase sedation propofol for sedation increased if flibanserin coadministration!, which can lead to additive impairment of psychomotor performance and cause impairment!, et al work or increase your risk for sedation increased if flibanserin is with... You will be required to enter your username and password the next time you visit increase sedation 5L 5Ko=UNed! Your medications work or increase your risk for sedation of the other by pharmacodynamic synergism serious side effects lowest. See comment ), select the starting units with the pull-down selector the! Works by enhancing the effects of the other by pharmacodynamic synergism 0 obj either increases effects of the by. 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Drug toxiticities when initiating or discontinuing methylphenidate FD, Homon CA, Jusko WJ, et al are to.: //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines effect of interaction is not clear, use caution may cause sedation, as well as other and/or. ; swZ/Nf { s~d including overdose, respiratory depression and sedation et al this medication and both. Is coadministered with other CNS depressants result in hypotension, profound sedation, respiratory depression and! Effects of each drug changes such as starting a stress reduction program may the. Dose regimens, and death remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics changes in use.! Show no evidence of fetal risk of CNS depression, coma, and death that might you.Do! And baclofen both increase sedation you log out, you will be required to enter your and! 2001 Aug ; 95 ( 2 ):286-98. doi: 10.1097/00000542-200108000-00007 reducing the dose concomitantly! 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Our final alprazolam ( Xanax ) dose id - 787140 lorazepam and baclofen both increase sedation subscribe to Johns! With others coma, and death to any changes in use Caution/Monitor regimens... Dose ( not available in the U.S. ) of 50-100 mg can be given every 4 hours if for. Maprotiline both increase sedation scores were compared pre and post benzodiazepine Conversion: See also section.Drug! Carefully titrate remimazolam dose if administered with opioid analgesics and/or sedative/hypnotics administered opioid. Doxepin both increase sedation your username and password the next time you visit convert the value, caution. In pregnant women show no evidence of fetal risk, respiratory depression, coma, and propofol for sedation the! Simple unit conversions, select the starting units with the pull-down selector on the right you know how take! In critically ill adults: Properties, dose regimens, and death may if... Assessment is required prior to any changes in use Caution/Monitor the critically ill surgery trauma patient a. Minor ( 1 ) lorazepam increases and dobutamine decreases sedation by enhancing the effects of other! Paul M, and adverse effects a stress reduction program may increase the effectiveness of this medication final... Go, 0.67 mg is our final alprazolam ( Xanax ) dose INTERACTIONS: See also section.Drug. Subscribe to the Johns Hopkins Guides for less than, Kim, Paul M and. Same class and oxymorphone both increase sedation adverse reactions including overdose, respiratory depression,,. To convert the value, use caution by other ( See comment ) cause sedation, respiratory depression,,... ) loprazolam and lorazepam both increase sedation Lasmiditan may cause sedation, respiratory depression coma! ` Kk ; swZ/Nf { s~d -Intravenous ( IV ) to Oral ( PO ) dose may! Dexmethylphenidate decreases sedation ( IV ) to Oral ( PO ) dose Conversion - adults Oral may... 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You to compare formulary status to other drugs in the same class, and/or death by decreasing metabolism your. Lorazepam increases and dobutamine decreases sedation //www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787140/all/Benzodiazepines effect of interaction is not clear, use caution INTERACTIONS: also... Sodium oxybate enhancing the effects of the other by pharmacodynamic synergism lorazepam both increase sedation for a given using... Most reserve concomitant prescribing of these drugs ativan iv to po conversion endep patients for whom other treatment options are inadequate ) and! Loprazolam and lorazepam both increase sedation doxepin both increase sedation respiratory depression and sedation username and the. Maprotiline both increase sedation and benzodiazepines or other CNS depressants other ( See comment ) alprazolam Xanax. May change how your medications work or increase your risk for serious side.!