It is hoped that this working group will lead to additional fora for future discussions of these important issues. Registered company in England and Wales (4325234) and the Isle of Man (5713F). ...it affect them? Their goals included the better recognition of disease variants and an improved classification of patients into distinct and relevant subgroups. One area of research that should receive increased emphasis in the near future is the study of interactions between tumor cells and the surrounding cells and stromal elements. It is also important to identify improved methods for recruiting patients into the trials. A number of caveats were seen as important when referring to FEPC. March 6, 2014 Check samples if you need inspirations on topic and information sources. Two requirements to facilitate this process were identified. Many medical treatments would not have been possible to find if it was not by animal testing, including some cures for cancer and HIV drugs, insulin, antibiotics, vaccines and many more2. and The current size of the scientific community in pancreatic cancer remains far inadequate to attain the necessary pace of discovery—a work force 20–100 times larger was thought to be more comparable with the tasks at hand and also more comparable with the efforts now devoted to other major cancer types. However, experience with gemcitabine has shown that a drug active in pancreatic cancer is likely to translate into a treatment with wide application for more common cancers. Read the latest cancer news on topics ranging from prevention to treatment. In 2000, an estimated 28,300 patients were diagnosed with pancreatic cancer in the United States These patients can expect to benefit from some progress in management. Biliary and Pancreatic Ductal Epithelia: Pathobiology and Pathophysiology, NIEHS/AACR Task Force on the Advancement of Minorities in Science: Vision for a Model Program, Cancer Epidemiology, Biomarkers & Prevention, Cachexia and Insulin-Resistance in Pancreatic Cancer Patients, Pancreas Cancer Think Tank Working Groups. This If your discipline is child care, it’s advisable to research works by other writers to understand challenges and relevant issues before choosing researchable topics in nursing that deal with young patients. Current Topics in Occupational Epidemiology. 61) (62 The American Institute for Cancer Research believes that there is a relationship between cancer and diet, body weight, and the physical activity of a person. Some participants stated that they would follow the natural course of these patients while collecting specimens prospectively and banking them. Some participants felt that using biological markers to decide upon pancreatectomy would have to await long-term studies addressing the predictive value of such markers. and with strategies that allow more rapid testing of new therapies. She was a daughter, a mother of two sons, a stepmother, grandmother, a wife, a sister, an aunt, a best friend to many, a manager of employees who absolutely adored her. . 100 Technology Paper Topics for Research Papers. NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. Diet is playing an important role in the recovery process. The volunteers are interested in these strategies as it parts of their work and they have to go by those strategies to do the job properly, they will want to do the job properly as it can be a very good experience and can be seen as an achievement working for a charity. (39, This list included: (a) the development of molecular markers to predict outcome; (b) the development of noninvasive techniques to evaluate the mechanisms of action (such as apoptosis) of new agents; and (c) the identification of surrogate markers of objective response or improved survival, such as circulating biomarkers or new imaging techniques. Having a comprehensive list of topics for research papers might make … A FIGHTING CHANCE FOR MORE TOMORROWS 3 Essay on nursing process and skin cancer research paper topics Identify your main reasons, evidence, and the subsequent market entry on an organizational structure: Space time compression notions, they take more blacks, but whose own professional interests and goals focusing on gender issues would be a two volume work shirley. Check out this awesome Lung Cancer In Non-Smokers Research Papers Examples for writing techniques and actionable ideas. I do not know what that organ does or what it is used for. J. Information for public A lot of people, however, are under the mistaken belief that the issue of skin cancer is only limited to the ones that are found on the face. Healthcare Management Topics. One proposal to address this problem was to develop a system whereby patients who die of pancreatic cancer can donate selected organs for research. 17, 18, A dietitian will discuss the right food options for that patient-the right care plan that will recommend the right diet, a high protein, enriched with fruits and vegetables and maintaining a healthy body weight. Research should be aimed at improving the cancer experience and long-term outcomes through the systematic development, evaluation and dissemination of interventions. List of best research paper topics 2020. 29) 42) Medical researches use animals to study cancer for a variety of reasons. Previous experimental evidence The following report summarizes this meeting and represents a first step at identifying the key research opportunities and required infrastructure needed to advance our knowledge about this difficult malignancy. Breast Cancer Research and Treatment provides the surgeon, radiotherapist, medical oncologist, endocrinologist, epidemiologist, immunologist or cell biologist investigating problems in breast cancer a single forum for communication. One of the most interesting controversial research topics is cancer research paper. dr248 Fischer, k. The main reason for this is the fact that the disease is seldom treated by surgical resection and is otherwise highly inaccessible for obtaining biopsies. In summary, a plan of attack for improving therapy for pancreas cancer was formulated by the working group. 150 Science Essay Topic Ideas. Specifically, it should now be possible to develop transgenic animal models that incorporate serial gene expression of these tumor suppressor genes and oncogenes to simulate the gene alterations that occur in pancreatic adenocarcinomas. Additionally, targets within the tumor’s microenvironment, including endothelial cells and stromal cells, should be considered Research Paper Topics on organ Transplantation. It was perceived that this could best be achieved by the use of a panel of biological markers in association with imaging studies, again stressing that this should be done in the context of a research protocol. Clinicians are most often responsible for the recognition of affected families, and need to be familiar with inheritance patterns that predispose to pancreatic cancer. This type of research (discovery) often does not include highly structured hypotheses, because it comprises the observation component of the scientific method and, consequently, often is not well received by conventional study sections at NIH. 12) An enhanced outreach to the nonneoplastic diseases was envisioned as well, especially a need to better understand the relationships between exocrine and endocrine diseases (especially diabetes) of the pancreas. Mrs. Swain Even though there are researchers from the University of Minnesota who are against animal testing for cosmetics, animal testing for medical reasons and the development of new drugs and cures for diseases is supported1. Am. Information for public A full knowledge of the mechanism of the beneficial effect of EPA on cancer cachexia will provide vital information for the development of new agents. 2013 ⇓ Many patients are not referred to experienced centers, limiting access of patients to clinical trials. His example used the imaging technique of EUS in a cohort of high-risk patients with a 10% incidence of cancer at ∼65 years of age. What I Want to Learn However, the group was in total agreement that cachexia represents a major clinical problem in these patients and is an area where therapeutic improvements are likely to have a great impact. Without any doubt, the information given here will influence writing styles chosen besides being able to draft a thesis. , 9) This is just a sample Cancer research paper (Cancer research paper example) which cannot be used as your own paper. 2 Trustees, Directors and Managers: (65 The long term goal of diet changes is to prevent cancer from recurring. Or if you are a student looking for a science experiment, I have posted step-by-step instructions for a variety of projects and you can find a list of links in my article: Science Fair Experiments. Cancer cachexia is a complex syndrome that is directly responsible for the death of a large number of cancer patients and contributes to morbidity and mortality in many other cases. Cancer Research Print ISSN: 0008-5472 Journal of Cancer Research ISSN: 0099-7013 American Journal of Cancer ISSN: 0099-7374. Enter multiple addresses on separate lines or separate them with commas. There exists considerable hope that therapeutic advances also will benefit from these classifications, and that rational new therapies might be suggested by the genetic and other etiological insights that clarify the biological foundations of this disease. The costs of publication of this article were defrayed in part by the payment of page charges. lists various factors or cytokines involved in these processes and appropriate references. Participants in this group brought a wide range of expertise to the table, including surgery, medical oncology, radiation therapy, immunotherapy, and cancer biology. One set of questions concerned implementing trials. In an effort to focus on the issues and the research opportunities in pancreas cancer, a Think Tank was convened on September 16, 1999, in Park City, Utah. Available therapeutic agents for pancreatic adenocarcinoma: Do they warrant more study? Animals have shorter lifespans and more rapid generation times compared to humans, and disease progression moves forward at a more rapid pace, so results of studies using animals as models are obtained quicker3. Not only did the goals of the organization require continuously increasing financing but she also faced the challenge of convincing generous contributors to allow for less restrictive donations. There was a great deal of discussion about the recently published University of Washington experience that evaluated various imaging studies including EUS, computed tomography, and ERCP in pancreatic cancer-prone families Background of Personal Experience with Pancreatic Cancer This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. ⇓ PanIN-1A designates flat (nonpapillary) epithelial lesions composed of tall columnar mucin-containing cells that show slight or no atypia. Financial, legal, and ethical considerations provide barriers to the collection of the tissues, blood, and other archival resources necessary to better understand this disease. In parallel, we need to aggressively support and encourage the development of new, rationally derived therapies that target molecules that are identified as a result of studies aimed at dissecting pancreatic cancer genetics and biology. The Think Tank was sponsored by the NCI, the Lustgarten Foundation for Pancreas Cancer Research, and numerous industrial sponsors. . Details of this new nomenclature as well as representative examples of each lesion can be found on the World Wide Web. Animal models (particularly syngeneic models) offer the possibility of studying both temporal and spatial events; however, the biological properties of pancreatic tumors that are induced in many animal model systems are distinct from humans, and interpretation of these findings and extrapolation to the clinical setting. There is a need for seed money to establish banks of resources modeled after the successful sharing of CEPH family DNA samples and pedigree information. There was general consensus among the working group that the ideal histological stage that warrants aggressive intervention, such as a total pancreatectomy, and offers the best chance of cure would be an advanced precursor lesion (PanIN-3 or carcinoma-in situ). Big Mama was the backbone of our family, the life of the party, a giving as well as a very forgiving person no matter the circumstances. Environmental and occupational cancer: global prevention. Research to understand causes / risks, design & test interventions, Lowenfels’ analysis found that screening this high-risk cohort extended the life span an average of 3 to 4 months. 25, Cancer is a very complex disease and research geared towards learning more about its origin, progression, and treatments. . The greatest excitement among this working group concerned the opportunities to improve the study of inherited risks. Current models of carcinogenesis posit the accumulation of defects in a linear manner. Topics for Cancer Research Papers Related to Awareness and Activism Create a breast cancer research paper outline highlighting three breast cancer charities. Please join StudyMode to read the full document. An example would be to combine agents that target signaling pathways such as K-ras and HER-2/neu with agents that induce tumor killing through a non-cross-resistant pathway. While it obvious we are allowed to occur in confrontations. PanIN-1B designates epithelial lesions that have a papillary, micropapillary, or basally pseudostratified architecture but are otherwise identical to PanIN-1A. 3 Susan Paresky, Chief Development Officer for the Dana-Farber Cancer Institute had her work cut out for her. . Therefore, industry, the National Cancer Institute, and extramural investigators need to partner closely and invest more in the development of new agents for pancreatic cancer. “Familial” does not necessarily mean “hereditary.” Because of low penetrance of disease among carriers, only one or possibly no members with pancreatic cancer may be found within a particular family; i.e., syndromic does not refer to the bedside clinical recognition of an individual patient, but can require also a genetic laboratory component to the diagnosis and a constellation of risks rather than a constellation of clinical signs and symptoms. Apush essay prompts 2013; Finland; Essay about why william won the battle of hastings and breast cancer research paper topics. Animal models should be developed further and investigated to provide insight into the process of pancreatic cancer genesis and progression. . 2.0 Introduction----------------------------------------------------------------------------03 Most of the group felt that EUS was an appropriate first choice for an imaging technique in screening high-risk individuals, and all members of the working group believed it should only be done in a research setting. Within this report, cancer research is defined as research where the published results include ‘cancer’ or ‘oncology’ within the title, abstract, or list of keywords of the publications, as indexed in the Scopus database. 20) To understand how cancer develops and progresses, researchers first need to investigate the biological differences between normal cells and cancer cells. The way we have organized the topics for research papers can save you lots of time getting prepared to write your research paper. There was a general consensus regarding the importance of biological markers for the early detection of pancreatic cancer. Of the many research opportunities identified, the highest priority went to the development of relevant animal models, understanding premalignant events, and selection of appropriate new biological or biochemical targets for therapy. I know you're probably thinking the same thing my family was thinking "how could someone who had already survived a cancer be diagnosed with another cancer and a very deadly cancer at that." (7) ⇓ This weight gain is attributable to the accumulation of lean body mass with no change in adipose tissue or body water. Journal of Cancer Research ISSN: 0099-7013 40 Best Ideas of Research Paper Topics for College Students. . . Cancer Cancer research papers are custom written with any medical health direction that you wish. 24, It is well documented I could go on and on about this lovely lady we called Big Mama. At Memorial Sloan Kettering, scientific inquiry unites researchers with diverse expertise from across our academic programs and medical departments. Most malignant and metastatic adenocarcinomas of the pancreas resemble ductal epithelial cells morphologically In addition, pancreatic cells exist in the physical environment of the pancreas, which can be considered an additional spatial parameter. 4.3 Categorisation of Breast Cancer by Size--------------------------------06 It mainly concerns on the NHS breast screening programme, to clarify the reader about the coverage of breast screening and a further interpretation is also provided on the identification of the types of breast... StudyMode - Premium and Free Essays, Term Papers & Book Notes. Potential new therapeutic targets: How much emphasis should they receive? First, there needs to be a focused effort at developing relevant preclinical models for pancreatic cancer The profound cachexia associated with pancreatic cancer also includes characteristic abnormalities in carbohydrate metabolism and marked peripheral insulin resistance. For example, some investigators have suggested that the epithelial lesions which occur in the small and medium sized ducts and ductules of the pancreas are the precursors to infiltrating adenocarcinoma, and yet these duct lesions have been designated variously in the literature as “metaplasia,” “hyperplasia,” “hypertrophy,” and “neoplasia” (see Table 1 However, a complete understanding of the relationship of these lesions to each other and to pancreatic adenocarcinoma requires additional study. Pancreas cancer advocacy was represented through the Pancreas Cancer Action Network (PanCan). (22, This work focuses on the mechanisms that underlie fundamental processes such as cell growth, the transformation of normal cells to cancer cells, and the spread (metastasis) of cancer cells. Even within centers with access to a larger number of patients, it is difficult to obtain tumor tissue because a minority of patients are candidates for resection. All the genetics research topics above are excellent, and if utilized well, could help you come up with a killer research paper. In addition, the neovascularization of tumors is an important and currently popular area of research. This has led many to postulate that the transformed cell type is in the ductal epithelial cell lineage. ⇓ The Code provides 12 ways that individuals can reduce their risk of developing cancer, and is a joint project between IARC and the European Commission. New targets for pancreatic cancer therapy are likely to arise from a better understanding of pancreas cancer biology. For the research paper on breast cancer, "Breast Cancer – the Destruction close to the Heart" would be a good title. The development of clinically relevant animal models and improved access to patient tumor tissue will greatly facilitate progress in the identification of new biologically relevant targets for therapeutic manipulation. 23, (10, However, there were concerns expressed with the latter approach related to the fact that these findings may not be applicable to all pancreatic cancer-prone families because of the heterogeneous make-up of these families. Can diet play apart in the healing process of cancer? Major goals related to the study of FEPC include the establishment of a large collaborative research effort and database made possible by new resources but preceded by the coordination of current databases based in a core center. The person is left weak, hurting and immune compromised after chemotherapy and radiation; therefore, dietary guidelines play an important part in the rebuilding of a healthy cancer free person. Second, there needs to be a focused effort to collect and store pancreatic adenocarcinoma tissue. It was recognized that the neoplastic nature and the precursor potential of many of PanINs-1A has not been established, and some investigators may therefore choose to add the modifier [L] (for lesion) to PanINs-1A (i.e., PanIN-1A [L]; Refs. The participants all agreed that there is an urgent need to test new treatment approaches more rapidly. . Erosion of skeletal muscle is a major contributory factor in the poor survival of these patients, leading to death by respiratory failure and hypostatic pneumonia. Cancer Vaccines (PDF) This knowledge should then lead to the rapid identification of important therapeutic targets. Each year, scientists find out more about what causes the disease, how to prevent it, and how to improve treatment. Three primary model systems for studying pancreatic adenocarcinoma were discussed. Can Diet Play A Role in Cancer? of the pancreas may progress from adenomas to borderline tumors to intraductal carcinomas and then to invasive carcinomas. Table 2 We do not retain these email addresses. 19, Anyone who crossed her path she greeted them with a smile and ALWAYS treated others with such respect & would give her shirt off her back to a stranger if they asked her for it. heterogeneity of FEPC How to Write a Research Paper The research Process. PanIN-3 epithelial lesions are usually papillary or micropapillary, but they are rarely flat. Research paper topics cancer for ocassion speech. No borders were seen for these goals, in that there remains hope that general models will emerge to aid the understanding of multiple tumor types as well as that considerable cross-pollination between various tumor types and scientific disciplines would continue to enrich the overall problem of controlling cancer. Ways to prevent the development of cancer. “In many cases, although not all, the use of animal experimentation is not only justified ethically, but essential to maintain the health and wee-being of human beings.” (Pro) . Discussions were focused on several specific topics: (a) the nature of cells that become transformed in the pancreas; (b) the process of transformation; (c) the process of invasion and metastasis; (d) strategies to identify molecules involved in transformation and metastasis; and (e) preclinical models for studying transformation and metastasis. It is hoped that such studies will form a foundation for the development of new screening tests for the early detection, and possibly the prevention, of pancreatic cancer. Cancer Thesis ment: Cancer is a painful, progressive disease with a high rate of mortality, when undetected and/or not administered the right chemotherapeutic agent(s). Therefore, besides choosing a topic, you are most interested in, and one with sufficient research materials ensure you. The members felt that their work was highly translational, having a practical importance for the ultimate benefit of pancreatic cancer patients. The processes of invasion and metastasis are more poorly understood than the process of transformation. Therefore, most professors encourage students to ask for help in order to have the best possible ground statement for their research proposal topics. The group unanimously agreed to adopt the designation Pancreatic Intraepithelial Neoplasia, or PanIN, as originally proposed by Klimstra and Longnecker , for these lesions. In addition to anorexia, cachexia is characterized by muscle wasting, weakness, and weight loss that progress until the time of death. , 35) Does epigenetics play a role in cancer? Also, it was hoped that the term “neoplasia” in the definition would foster the additional study of these lesions. Cancer was deemed fearful and put most in denial back then, so a lot of doctors wouldn’t tell their patients they had cancer and out of those that were told, those patients didn’t tell their family members. More importantly, every patient with an abnormal ERCP had an abnormal EUS that demonstrated echogenic foci, hypoechoic nodules, or an echogenic main duct. Research paper topics cancer for ocassion speech. 4.2 Breast Cancer Detection by Age Group---------------------------------05 The process known as Metastasis occurs when cancer cells travel to other parts of the body via the bloodstream and replace normal tissue. Therefore, the overall goals of the working group on therapy were: (a) to identify specific areas of pancreatic cancer therapeutics that require progress; and (b) to generate a plan of attack to facilitate rapid progress in sorting through selected new treatment approaches. In the short term, there is a need for the discovery of the remaining uncharacterized genetic defects in human pancreatic tumors, additional hypotheses that explain the acquisition of these defects, and models to test these hypotheses. Currently, overall survival, time-to-tumor progression, and objective response are still the most common end points used in clinical trial design. How can we do it faster? Most current hypotheses posit that a number of molecular alterations (mutations) occur over time and result in transformation when an appropriate set of alterations accumulate in a cell or in a population of cells. Is the society becoming too casual about the approach to take strict action for curing breast cancer? This goal comes with a tremendous and ever increasing price tag. We have created this page to help you narrow it down to the specific focus. ISBN 978-953-51-0183-3, PDF ISBN 978-953-51-6861-4, Published 2012-03-02 Quality of life and symptom relief are also considered end points; however, these studies are more labor intensive. The attainment of adequate family histories is complicated by the late onset of pancreatic cancer, the high variety of other cancer types to be seen in susceptible families, and the low penetrance for the disease among persons with inherited susceptibility. . 5, Of particular interest is recent progress with the polyunsaturated fatty acid EPA, a fish-derived n-3 fatty acid. Anderson Cancer Center, Houston, TX, Janina Baranowska-Kortylewicz—University of Nebraska Medical Center, Omaha, NE, Anton Bilchik—John Wayne Cancer Institute, Santa Monica, CA, David Carbone—Vanderbilt University Medical Center, Nashville, TN, Paul Chiao—Memorial Sloan-Kettering Cancer Center, New York, NY, Daniel Laherue—Johns Hopkins Medical Institutions, Baltimore, MD, Kim Lyerly—Duke University, Chapel Hill, NC, Cornelius McGinn—Michigan University, Ann Arbor, MI, Neal Meropol—Fox Chase Cancer Center, Philadelphia, PA, Eileen O’Reilly—Memorial Sloan-Kettering Cancer Center, New York, NY, Mace Rothenberg—Vanderbilt University Medical Center, Nashville, TN, Margaret Tempero—University of Nebrask Medical Center, Omaha, NE, Paula Termuhlen—University of Nebraska Medical Center, Omaha, NE, Steve Tucker—John Wayne Cancer Institute, Santa Monica, CA, Daniel Von Hoff—University of Arizona Cancer Center, Tucson, AZ, Christopher Willett—Massachusetts General Hospital, Boston, MA, Charles Yeo—Johns Hopkins Medical Institutions, Baltimore, MD, List of recommended terms with synonyms for focal proliferative and metaplastic lesions in the human exocrine pancreas. 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